非霍奇金淋巴瘤患者血清胰岛素样生长因子-1及其结合蛋白-3表达水平的初步观察

Observation on the expressions of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in non-Hodgkin's lymphoma

目的:探讨非霍奇金淋巴瘤(NHL)患者血清胰岛素样生长因子-1(IGF-1)及其结合蛋白-3(IGFBP-3)表达水平及其临床意义。方法:选择28例诊断初发NHL患者(淋巴瘤组)及28例健康志愿者(对照组),化学发光法测定血清IGF-1及IGFBP-3水平并计算IGF-1/IGFBP-3值,分析组间的差异。结果:血清IGF-1及IGFBP-3水平淋巴瘤组显著低于正常对照组(均P<0.01);IGF-1/IGFBP-3淋巴瘤组与正常对照组差异无统计学意义(P>0.05);不同亚型的淋巴瘤组的血清IGF-1、IGFBP-3水平及IGF-1/IGFBP-3比值的差异均未达到统计学意义(P>0.05)。结论:NHL患者血清IGF-1及IGFBP-3水平明显降低,可能与NHL相关。IGF-1/IGFBP-3比值与NHL无明显相关性,IGF-1及IGFBP-3水平与NHL的分型无明显相关。

Objective：To investigate the expressions of serum insulin-like growth factor-1 （IGF-1） and insulin-like growth factor binding protein-3 （IGFBP-3） in patients with non-Hodgkin＇s lymphoma （NHL） and its clinical significance.Methods：Twenty-eight cases with newly diagnosed NHL and 28 cases of healthy volunteers were involved in the study.Serum levels of IGF-1 and IGFBP-3 were determined by the method of chemical luminescence,and ratio of IGF-1/IGFBP-3 was counted.The differences were compared between two groups.Results：Serum levels of IGF-1 and IGFBP-3 were significantly lower in NHL group than those in control group （P0.01）,but there was no difference in the ratio of IGF-I/IGFBP-3 between two groups （P0.05）;and there were no differences in serum levels of IGF-1,IGFBP-3 and the ratio of IGF-1/IGFBP-3 among different types of non-Hodgkin＇s lymphoma （P0.05）.Conclusions：Serum levels of IGF-1 and IGFBP-3 significantly decreased in patients with NHL,and might relate with NHL.The ratio of IGF-1/IGFBP-3 has no obvious correlation with NHL.Serum levels of IGF-1 and IGFBP-3 have no obvious correlation with types of NHL.