E-钙粘蛋白在肿瘤中的表达与分化转移的关系

E-Cadherin Expression in Carcinoma and Relation to Differentiation and Metastasis

目的 研究Ｅ钙粘蛋白（Ｅｃａｄｈｅｒｉｎ）在胃癌、结直肠癌、宫颈癌、乳腺癌中的表达与肿瘤分化程度，侵袭转移等生物行为的关系及在４种癌症中表达的相互关系。方法 用免疫组织化学ＡＢＣ法检测２０例胃癌、２１例结直肠癌、２０例宫颈癌、２０例乳腺癌石蜡标本Ｅ钙粘蛋白的表达水平。结果 Ｅ钙粘蛋白在４种肿瘤中的表达有一定的相似，即癌组织较癌旁组织的表达水平低，高中分化肿瘤比低分化肿瘤表达水平高。Ｅ钙粘蛋白在不同转移情况肿瘤中的表达结果差异不明显。结论 Ｅ钙粘蛋白癌旁组织中的表达明显高于癌组织，并与分化程度有直接关系；与转移的关系比较复杂，有待于进一步研究。Ｅ钙粘蛋白在４种肿瘤中的表达有一致性，所以Ｅ钙粘蛋白免疫组织化学研究有一定的临床病理价值。

Purpose To obtain the pattern and extent of reactivity has be correlated with clinicopathological data including tumor type,grade,and hymph node status,expression of E cadherin. Methods Expression of E cadherin has been examined in 20 gastric carcinomas;21 colorectal carcinomas;20 uterocervical carcinomas and 20 breast carcinomas using an immunohistochemical technique. Results There are similar pattern among four kinds of cancer.Tumors with a decrease in E cadherin occurred significantly more frequently in poor differentiated carcinomas.There was association between membrane levels of E cadherin and the pre sence of lymph node metastasis but the difference is not significant. Results There are similar pattern among four kinds of cancer.Tumors with a decrease in E cadherin occurred significantly more frequently in poor differentiated carcinomas.There was association between membrane levels of E cadherin and the pre sence of lymph node metastasis but the difference is not significant. Conclusions E cadherin expression of the noncancerous areas ins highter than that of the cancerous areas.The decreased E cadherin expression correlates with dedifferentiation.The relation between the E cadherin expression and the metastasis is complex and need much more research.There are similar pattern among four types of cancer.For that,immunohistochemical study of E cadherin may have clinicopathologic value for patients with cancer.