期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

表观遗传学和肾脏疾病 被引量：1

Epigenetics and kidney disease
下载PDF
导出
摘要 表观遗传学是研究基因的核苷酸序列不发生改变的情况下发生可遗传修饰的一门学科。表观遗传机制包括DNA甲基化、组蛋白修饰、基因组印记、母体效应、基因沉默和非编码RNA的调控作用等。目前,对于表观遗传学的研究主要集中在DNA甲基化、组蛋白修饰和非编码RNA的调控上,其机制在肾脏疾病的发生和发展中亦起重要作用。 Epigenetics is a study of heritable changes during gene expression where DNA sequences don＇t change. The current research field of epigenetics includes DNA methylation, histone modification, genomic imprinting, maternal effects ,non-coding RNA and gene silencing, etc. Current epigenetic researches mainly focus on DNA methylation, histone modifications and the regulation of the non-coding RNA. Epigenetic mechanisms also play important roles in the development and progression of kidney diseases.
作者 徐忠秀 秦卫松
机构地区 南京军区南京总医院全军肾脏病研究所
出处 《肾脏病与透析肾移植杂志》 CAS CSCD 北大核心 2012年第2期164-169,共6页 Chinese Journal of Nephrology,Dialysis & Transplantation
关键词 表观遗传学 环境 肾脏疾病 epigenetics environment kidney disease
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献35

  • 1Feinberg AP. Methylation meets genomics. Nat G;ericl. 2001, 27 (1):9-10.
  • 2Weber M,,Hellmann I,Stadler MB,et al distribution ,silencing potential and evolutionary impact ofpromoter DNA methylation in the human genome Nat Gent,,2007,39(4) :457 -466.
  • 3Okano M, Bell DW. Haber DA ,er al DNA methyltrandferases Dnmt3a and Dnmteb are essential for de novo methylation and mammalian development Cell , 1999.99( 3 ) :247 -257.
  • 4Bird AP. Wolffe Ap Methylation-induced repression -belts ,braces,and chromatin Cell,1999,99(5):451 -454.
  • 5Tahiliani M, Koh KP,Shcn Y,el al. Conversion of 5-mlhylcytosine to 5-hydroxym-'tllylcytosine in mammalian DNA by M1,L partner TETI. Srience ,2009,324 ( 5929 ) :930 - 935.
  • 6Jenuwein T, Allis CD. Translating the hislone c-tt-. Science, 2001, 293 ( 5.532 ) : 1074 - 1080.
  • 7I|an J, Kim D, Morris KV. [h'omoter-ass-'iated RNA is required fi-r RNA-directed transcriptional gene silencing in human c-lls. PrCx- Natl Acad Sci U S A,2007,104(30) :12422 - 12427.
  • 8Kawasaki H,Taira K,Morris KV. siRNA induced transcriptional gene silencing in manunalian cells. Cell Cycle,2005,4( 3 ) :442 -448.
  • 9lx-wis BP, Burge CB, Bartel DP. Conserw'd seed pairing.cfften Ilank-d by adenosin-s,indicates that thousands of human genes are microRNA targets. Cell ,2005,120( I ) :15 -20.
  • 10l,in H. piRNAs in Ihe germ lint,. St:iene,2007,316(5823 ) :397.

二级参考文献34

  • 1吴燕,刘志红.有机溶剂与肾脏疾病[J].肾脏病与透析肾移植杂志,2006,15(1):72-76. 被引量：7
  • 2王金泉.有机溶剂相关性肾小球膜性病变及肾小管间质损害[J].肾脏病与透析肾移植杂志,2006,15(1):95-100. 被引量：3
  • 3Churchill DV, Fine A, Gault MH. Association between hydrocarbon exposure and glomerulonephritis. An appraisal of the evidence. Nephron, 1983, 33 : 169 - 172.
  • 4Damiell WE, Couser WG, Rosenstock L. Occupational solvent exposure and glomerulanephritis: a case report and review of the literature. JAMA, 1988, 259:2280-2283.
  • 5Roy AT, Brautbar N, Lee DB. Hydrocarbons and renal failure. Nephron, 1991,58 : 385 -392.
  • 6Yaqoob M, Bell GM, Stevenson A, et al. Renal impairment with chronic hydrocarbon exposure. Q J Med, 1993, 86:165 -174.
  • 7Zimmerman SW, Groehler K, Beime GJ. Hydrocarbon exposure and chronic glomerulonephritis. Lancet, 1975, 199-201.
  • 8Nuyts GD, Van Viem E, Thys J, et al. New occupational risk factors for chronic renal failure. Lancet, 1995, 346: 7-11.
  • 9Ravnskov U. Experimental glomerulonephritis induced by hydrocarbon exposure: a systematic review. BMC Nephrology, 2005, 6:15.
  • 10Radican L, Wartenberg D, Rhoads GG, et al. A retrospective occupational cohort study of end-stage renal disease in aircraft workers exposed to trichloroethylene and other hydrocarbons. J Occup Environ Med, 2006,48:1 -12.

共引文献13

同被引文献24

  • 1Chun Zhang,Krishna M. Boini,Min Xia,Justine M. Abais,Xiang Li,Qinglian Liu,Pin-Lan Li.Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia[J]. Hypertension . 2012 (1)
  • 2Xue?Bo Han,Hui?Ping Zhang,Cheng?Jian Cao,Yan?Hua Wang,Jue Tian,Xiao?Ling Yang,An?Ning Yang,Jie Wang,Yi?Deng Jiang,Hua Xu.??Aberrant DNA methylation of the PDGF gene in homocysteine?mediated VSMCproliferation and its underlying mechanism(J)Molecular Medicine Reports . 2014 (2)
  • 3Chuong NM,Lardy B,Paclet MH,et al.NADPH oxidases,Nox:new isoenzymes family. Medical Science Research . 2015
  • 4Perna A F,Satta E,Acanfora F,Lombardi C,Ingrosso D,De Santo N G.Increased plasma protein homocysteinylation in hemodialysis patients. Kidney International . 2006
  • 5Yang XL,Tian J,Liang Y,Ma CJ,Yang AN,Wang J,Ma SC,Cheng Y,Hua X,Jiang YD.Homocysteine induces blood vessel global hypomethylation mediated by LOX-1. Genetics and Molecular Research . 2014
  • 6Xia M,Conley SM,Li G,et al.Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion. Cellular Physiology and Biochemistry . 2014
  • 7Castro Rita,Rivera Isabel,Struys Eduard A,Jansen Erwin E W,Ravasco Paula,Camilo Maria Ermelinda,Blom Henk J,Jakobs Cornelis,Tavares de Almeida Isabel.Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clinical Chemistry . 2003
  • 8Gowacki, Rafa,Jakubowski, Hieronim.Cross-talk between Cys<sup>34</sup> and Lysine Residues in Human Serum Albumin Revealed by N-Homocysteinylation. Journal of Biological Chemistry . 2004
  • 9Zhou Ji,Werstuck Geoff H,Lhoták Sárka,Shi Yuan Y,Tedesco Vivienne,Trigatti Bernardo,Dickhout Jeffrey,Majors Alana K,DiBello Patricia M,Jacobsen Donald W,Austin Richard C.Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology . 2008
  • 10Ines Sanchez-Roman,Alexia Gomez,Carlota Sanchez,Henar Suarez,Monica Lopez-Torres,Gustavo Barja.Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro. Journal of Bioenergetics and Biomembranes . 2011

引证文献1

二级引证文献10

肾脏病与透析肾移植杂志
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部