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丝裂原活化蛋白激酶信号通路在吗啡依赖中的作用 被引量：2

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摘要 丝裂原活化蛋白激酶（mitogen-activated protein kinase,MAPK）是一类广泛分布于细胞内的丝氨酸/苏氨酸蛋白调节激酶,通过磷酸化而活化。活化前的MAPK位于胞浆,一旦活化即进入核内激活靶基因。MAPK信号转导通路调节细胞的多种生理过程，如细胞生长、分化、凋亡等，是近年来信号转导方面最活跃的研究领域之一。近年来有研究表明，MAPK与镇痛及吗啡依赖的形成关系密切。
作者 张乐 朱永平
机构地区 浙江大学医学院毒理研究室
出处 《中国药物依赖性杂志》 CAS CSCD 2012年第2期100-105,共6页 Chinese Journal of Drug Dependence
基金 国家重点基础研究发展计划(973计划)项目(2003CB515400) 浙江省科技计划重点项目(2005C23G2010166) 卫生部科学研究基金(省部共建项目计划)(WKJ2007-2-007)
关键词 丝裂原活化蛋白激酶 吗啡依赖 MAPK信号转导通路 信号通路 protein 调节激酶 过磷酸化 生理过程
分类号 R644 [医药卫生—外科学]
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参考文献10

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二级参考文献43

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共引文献37

同被引文献17

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  • 2王永生,魏子峰,田清友,张作凤,周洪霞,张宇新.JNK通路在亚急性帕金森病模型小鼠黑质细胞炎症与凋亡过程中的调控作用[J].临床与实验病理学杂志,2007,23(5):601-605. 被引量：6
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引证文献2

二级引证文献4

中国药物依赖性杂志
2012年 第2期

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