原发性皮肤黏液癌

Primary mucinous carcinoma of the skin

报告1例原发性皮肤黏液癌。患者男,41岁。右颧部出现结节2年,无其他自觉症状。皮肤科检查:结节呈肤色,质韧,表面光滑,与周围组织无明显粘连,大小约1 cm×1 cm。皮损组织病理检查:肿瘤位于真皮,累及皮下脂肪,黏蛋白中混杂肿瘤团块,肿瘤细胞可见腺样分化,未见明显核分裂象。免疫组化结果示阳性,尾型同源盒转录因子(CDX)2、绒毛波形蛋白(Villin)、甲状腺样转录因子(TTF1)、前列腺特异性抗原(PSA)均阴性。结合组织病理及免疫病理特点诊断为原发性皮肤黏液癌。

A 41-year-old man complained of a tumor on his right malar region for two years. Physical examination showed a firm, skin-colored, movable nodule measured 1 em in diameter. He felt no subjective symptoms. Histopathological examination showed that there was abundant mucin in tile dermis which was separated by fibrous septa. Fat was involved in the tumor. Some agglomerate epithelial cells, with glandular differentiation, were floating in the background of mucin. There were a few mitotic figures. Immunohistochemical results revealed the tumor cells were stained positive for CK7, and negative for CDX2, Villin, TFFI, CK20 and PSA. He was diagnosed as primary mueinous carcinoma of the skin according to histopathological and immunohistoehemical characters.