CK-19 mRNA对乳腺癌的微转移诊断价值的Meta分析

Meta analysis on the diagnostic value of CK-19 mRNA in the breast cancer micro metastasis

目的：评价CK-19mRNA对乳腺癌的微转移诊断的价值。方法：计算机检索维普、CNKI和万方数据库,收集已公开发表的有关CK-19 mRNA对乳腺癌的微转移诊断的文献,按Meta分析的要求对原始文献的质量进行评估,采用RevMan5.0软件对各研究的原始数据进行统计分析。结果：共纳入7篇中文文献,样本量为777例,其中经病理学诊断为II、I期的乳腺癌患者为258例,III、Ⅳ期的有62例。乳腺癌组与乳腺良性疾病组的Meta分析结果：合并OR=7.30,95%CI=2.48~21.44,P=0.0003;I、Ⅱ期与III、Ⅳ期癌症组的Meta分析结果：合并OR=0.20,95%CI=0.11至0.38,P〈0.00001。结论：CK-19 mRNA可以作为检测乳腺癌患者外周血微转移的分子标志物,对乳腺癌的指导治疗和评估预后具有重要的意义。

Objective：To evaluate the diagnostic value of CK-19 mRNA in breast cancer micro metastasis.Methods：Weipu,CNKI and Wanfang Database were used to search all the relevant texts which are about the diagnostic value of CK-19 mRNA in the breast cancer micrometastasis.The quality of the retrieved original studies was evaluated according to the requirements of Meta analysis.All data were analyzed by Review manager 5.0.Result：Seven Chinese studies were collected.The sample size was 777 cases,of which 258 cases confirmed pathologically were in stage I-II and 62 cases in stage III-IV.The Meta analysis result between the patients and the benign breast disease showed OR=7.30,95%CI=2.48-21.44,P=0.0003.The Meta analysis result between the patients in stage I-II and III-IV showed OR=0.20,95 % CI=0.11-0.38,P0.00001.Conclusion：CK-19 mRNA can be used as a molecular maker in peripheral on the micro metastasis of the breast cancer,and it can provide important information for estimating prognosis and guiding clinical therapy of breast cancer.