脐带血邻苯二甲酸酯水平及影响因素

Phthalate Esters Levels in Umbilical Cord Blood and Related Factors

目的:探讨澄海区新生儿宫内邻苯二甲酸酯(PAEs)暴露水平及其影响因素。方法:采用气相色谱-质谱联用仪,检测澄海区(暴露组)127例,濠江区(对照组)60例新生儿脐带血血清中5种PAEs水平,并做相关因素问卷调查。结果:暴露组脐带血样本中邻苯二甲酸丁苄酯,邻苯二甲酸二乙基己酯,邻苯二甲酸二正辛酯(DnOP)浓度中位数分别为24.1,648.6,10.1μg/L,显著高于对照组(22.9(P<0.05)、492.8(P<0.01)、7.2μg/L(P<0.001));DnOP水平升高与母亲年龄、喝茶习惯负相关。结论:澄海区产妇和新生儿PAEs暴露处于较高水平,采取有效措施降低当地人群特别是母婴PAEs暴露,保护当地人群健康尤为重要。

Objective： To observe phthalate esters（ PAEs） levels and related factors from Chenghai area. Methods： One hundred and twenty-seven neonatal umbilical cord blood samples from Chenghai and 60 from Haojiang were collected. PAEs levels were determined by gas chromatography/mass spectrometry. Questionnaire was carried out among subjects. Results： The mean of butylbenzyl phthalate, di （2-ethylhexyl） phthalate, di-n-octyl phthalate （DnOP） levels （ 24. 1, 648.6, 10.1ug,/L）from Chenghai were significantly higher than Haojiang（22.9, P 〈0.05; 492.8, P 〈0.01; 7.2 ug/L, P 〈0.001）. DnOP level was negatively correlated with mothers＇ age and tea consuming. Conclusion： Pregnant women and neonates from Chenghai area are exposured to higher PAEs levels. Adopting effective measures to decrease local people＇s PAEs level are needed.