右美托咪啶用于纤维支气管镜检查麻醉的临床观察

Clinical Observation of Dexmedetomidine for Anesthesia of Fiberbronchoscopy

目的:观察右美托咪啶用于纤维支气管镜检查的麻醉效果。方法:120例纤维支气管镜检查的患者随机分为2组,A组使用利多卡因气雾剂+利多卡因隆突表面麻醉法,B组使用右美托咪啶法。观察2组不同时间点的心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)及不良反应发生情况。结果:A组HR、MAP均较术前明显上升,SpO2较术前明显下降;B组除HR下降明显、MAP轻度下降外其他指标无明显变化。2组比较差异均有统计学意义(P<0.05)。A组不良反应发生率均明显高于B组(P<0.01)。结论:右美托咪啶在纤维支气管镜检查的麻醉中能减少呼吸及循环抑制的发生,不良反应发生率低,是一种安全、有效的麻醉方法。

OBJECTIVE： To observe the anesthesia effect of dexmedetomidine for fiberbronchoscopy. METHODS： 120 patients underwent fiberbronchoscopy were randomly divided into 2 groups. Patients in group A were anesthetized by Lidocaine aerosol plus Lidocaine carina surface anesthesia, and patients were anesthetized by dexmedetomidine in group B. HR, MAP, SpO2 and adverse drug reaction were observed at different time points. RESULTS： HR, MAP of patients in group A increased and SpO2 decreased obviously compared with pre-operation. HR in group B decreased significantly, MAP decreased slightly but other indicators had no change. There was significant difference between group A and B （P0.05）. The incidence of adverse drug reactions in group A was more significant than in group B （P0.01）. CONCLUSION： Suppression of respiration and circulation are decreased by using dexmedetomidine for anesthesia of fiberbronchoscopy. Dexmedetomidine anesthesia was safe and effective with low incidence of ADR.