123I—β-甲基-p-碘苯基十五烷酸心肌显像研究进展

Advances in β-methyl-p-iodophenyl pentadecanoic acid myocardial imaging

脂肪酸代谢是心肌中最高效的供能方式。脂肪酸代谢水平的改变被认为是心肌缺血和心肌损伤最敏感的指标。心肌缺血后，尽管血液灌注已恢复，但脂肪酸代谢的长期抑制还会持续，这就是所谓的代谢顿抑或缺血记忆。用放射性核素标记β-甲基中-碘苯基十五烷酸（BMIPP）SPECT评估脂肪酸的代谢，对早期发现心肌缺血，评估缺血性冠状动脉疾病及心肌病的严重性及预后有重要的作用。该文对123I—BMIPP心肌显像的近期研究进展进行综述。

Fatty acid metabolism is the most efficient mode of myocardial energy production. Alteration of fatty acid metabolism is considered to be a sensitive marker of ischaemia and myocardial damage. After myocardial ischemia, prolonged suppression of fatty acid metabolism may persist despite restoration of blood flow, which is called metabolic stunning or ischemia memory. Assessment of fatty acid metabolism by radionuelide labeled β -methyl-p-iodophenyl pentadecanoic acid （BMIPP） SPECT plays a potential role in the early detection of myocardial ischaemia and the assessment of the severity of ischaemic coronary artery disease and myocardial disease. This article describes recent advances in 123I-BMIPP myocardial imaging.