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微环境与乳腺癌新辅助化疗

Tumor microenvironment and neoadjuvant chemotherapy in breast cancer
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摘要 肿瘤微环境对于肿瘤发生、发展的作用以及对辅助化疗、新辅助化疗疗效的影响越来越受到重视。研究表明乳腺癌微环境尤其是肿瘤间质纤维母细胞（CAF）及其合成的基质细胞衍生因子-1（SDF-1）和胶原，可对新辅助化疗产生重要的影响。 Recently many studies have focused on the roles that tumor microenvironment plays in the occurrence and development of tumors, and the therapeutic effects of adjuvant chemotherapy and neoadjuvant chemotherapy. Recent researches show that tumor microenvironment has an obvious impact on the therapeutic effects of neoadjuvant chemotherapy, which mainly includes cancer-associated fibroblasts （CAF） , stromal cell derived factor-1 （SDF-1） and collagens.
作者 荣国华 康骅
机构地区 首都医科大学宣武医院普外科
出处 《国际肿瘤学杂志》 CAS 2012年第4期272-274,共3页 Journal of International Oncology
基金 国家自然科学基金资助项目（81172517）
关键词 乳腺肿瘤 化学疗法 辅助 趋化因子CXCL12 微环境 Breast neoplasms Chemotherapy, adjuvant Chemokine CXCL12 Microenvironment
分类号 R737.9 [医药卫生—肿瘤]
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参考文献14

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  • 6蔡伟,刘丹丹,康骅,海涛,崔叶青,孙海晨.ET方案新辅助化疗对乳腺癌组织中CXCR4表达的影响及临床意义[J].中国普外基础与临床杂志,2010,17(8):812-815. 被引量：11
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二级参考文献27

  • 1康骅,Robert EMansel,Wen G Jiang.基质细胞衍化因子-1的表达及其与乳腺癌患者预后的关系[J].中国普外基础与临床杂志,2005,12(5):483-487. 被引量：7
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  • 5Kang H,Watkins G,Douglas-Jones A,et al.The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer[J].Breast,2005;14(5):360-367.
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  • 9Mayr D,Heim S,Werhan C,et al.Comprehensive immunohistochemical analysis of Her-2/neu oncoprotein overexpression in breast cancer:HercepTest(Dako)for manual testing and Her-2/neu Test 485(Ventana)for Ventana BenchMark automatic staining system with correlation to results of fluorescence in situ hybridization(FISH)[J].Virchows Arch,2009;454(3):241-248.
  • 10Kato M,Kitayama J,Kazama S,et al.Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma[J].Breast Cancer Res,2003;5(5):R144-R150.

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国际肿瘤学杂志
2012年 第4期

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