血管内皮生长因子与肺癌的治疗和预后

VEGF in the treatment and prognosis of lung cancer

在肺癌生长和转移的过程中，新生血管的生成能够促进肿瘤的生长和转移。血管内皮生长因子（VEGF）是目前已知最强的促血管生成因子，因此，抗VEGF治疗能够通过抑制新生血管的生成而成为肺癌靶向治疗的一种重要形式，同时，VEGF的表达对肺癌预后的判断同样有重要意义。

Angiogenesis plays a critical role in growth and metastasis of lung cancer. The strongest tumor angiogenesis factor known is the vascular endothelial growth factor （VEGF）. Therefore, anti-VEGF therapy which can restrain tumor angiogenesis is an important form of the targeted therapy of lung cancer. The expression of VEGF is also significant to the prognosis of lung cancer.