摘要
Wnt信号通路是体内重要的信号调节系统之一,而骨细胞作为骨组织中最主要的应力感受细胞,受载后可引起其内部Wnt信号通路的快速激活,最终调节其基因表达,影响骨改建。该激活过程受诸多调控因子的影响。本文就Wnt信号通路与骨细胞生物力刺激信号转导间的关系,以及该信号转导过程中Wnt信号通路的调控因子等研究进展作一综述。
As one of the most important regulatory systems,Wnt signaling pathway is stimulated very quickly by biomechanical stimulation in osteocytes,which function as key mechanosensory cells in bone.The stimulating procedure is influenced by lots of factors and finally results in regulation of gene expression and bone remolding.This review concludes the research advances concerning the relationship between Wnt signaling pathway and mechanotransduction in osteocytes,and major regulatory factors on the pathway＇s stimulation.
出处
《国际口腔医学杂志》
CAS
2012年第3期328-331,共4页
International Journal of Stomatology
关键词
WNT信号通路
骨细胞
生物力刺激
信号转导
Wnt signaling pathway
osteocyte
biomechanical stimulation
signaling transduction
