比较丙泊酚和右美托咪啶用于静脉镇静：对中枢和自主神经系统作用的随机交叉研究

我们比较了丙泊（propofol，PROP）和右美托咪啶（dexmedetomidine，DEX）镇静对心理应激状态下的志愿者的自主神经活性和主观感觉的影响。在交叉设计中，25例受试者输注PROP和DEX直至双频指数值达到75-85，对心率、心率变异率、α-唾液淀粉酶（客观指数）、表情焦虑量表（主观指数）进行评估。询问受试者在两种镇静剂中更偏好哪一种。两组中客观指数的改变相似，表情焦虑量表评分仅在PROP组下降，受试者也更偏爱PROP。与DEX相比，丙泊酚镇静能更有效地抑制焦虑。

We compared, in volunteers, the effect of propofol （PROP） and dexmedetomidine （DEX） sedation on auto- nomic nervous activities and subjective feelings during psychological stresses. In a crossover design, 25 subjects received PROP and DEX titrated to a bispectral index value of 75 to 85. Heart rate, heart rate variability, and salivaly a-amylase （objective indices） and a faces anxiety scale （subjective index） were assessed. Subjects were asked their preference between 2 sedatives. Objective indices showed similar changes in both groups. The faces anxiety scale decreased only in the PROP group and sub- jects preferred PROP. Propofol more effectively suppressed anxious feelings compared with DEX during sedation.