四川结核病患者结核分枝杆菌耐药状况分析

The analysis on drug resistance of mycobacterium tuberculosis for tuberculosis patients in Sichuan province

目的了解结核患者的结核分枝杆菌的耐药状况,为耐药结核的防治提供参考依据。方法面对面调查结核病患者并收集患者的菌株材料。对收集的菌株材料进行菌种鉴定,然后采用绝对浓度法对结核分枝杆菌的菌株进行抗异烟肼(INH)、利福平(RF)、链霉素(SM)和乙胺丁醇(EMB)的耐药性检测,并分析结核分枝杆菌的耐药状况。结果 617株结核分枝杆菌菌株总耐药率和耐多药率分别为21.39%(132/617)、11.35%(70/617);初治患者的总耐药率和耐多药率与复治患者比较存在显著性差异。结论四川省结核患者耐药状况有所缓解,但耐药防治仍然不可忽视,需进一步加强耐药结核的监测和防控。

Objective To understand the status on drug resistance of mycobacterium tuberculosis in Sichuan,and to provide the evidence for tuberculosis treatment and control.Methods The tuberculosis patients were investigated by face to face interview and the clinical isolates of patients were collected.Mycobacterium tuberculosis were identified,and absolute concentration method was used to test the drug-resistance of isoniazide（INH）,rifampicin（RFP）,streptomycin（SM）,ethambutol（EMB）.The status on drug resistance of mycobacterium tuberculosis were analyzed.Results The total rate of drug resistance and the rate of multi-drug resistance were respectively 21.39% and 11.35%,and there was statistical significance between the total rate of drug resistance and multi-drug resistance of primary treatment patients and that of re-treatment patients.Conclusions There is a decrease in the drug resistant status of Sichuan,but it is still an importance of tuberculosis control and prevention,and we should further strengthen on its surveillance and control.