血清肌酸激酶同工酶的质量与活性测定在急性心肌梗死诊断中的价值

To Evaluate the Value of the Determination of Serum CK-MB Mass and Activity in Diagnosis of Acute Myocardial Infarction

目的探讨肌酸激酶同工酶(CK-MB)质量与活性的测定在急性心肌梗死(acute myocardialinfarction,AMI)早期诊断的价值。方法应用电化学发光法与酶免疫抑制法分别测定36例AMI患者、38例心绞痛患者(angina pectoris,AP)及30例正常对照组CK-MB的质量与活性。结果 AMI组患者CK-MB质量与活性达到峰值的时间完全相同,但CK-MB质量的升高倍数(18倍)明显高于CK-MB活性(7倍);AMI组患者CK-MB的质量与活性均明显高于AP组和正常对照组,差异有统计学意义(P<0.01),AP组的CK-MB活性高于正常对照组,差异有统计学意义(P<0.01),而AP组CK-MB质量与正常对照组比较,差异无统计学意义(P>0.05)。结论 CK-MB的质量与活性在急性心肌梗死早期诊断中都较敏感,但CK-MB质量的测定在对抗干扰因素方面明显好于CK-MB活性的测定。

Objective To evaluate the early diagnosis value of the determination of serum CK-MB mass and activity in acute myocardial infarction（AMI）.Methods The serum CK-MB mass and activity were determined by electrochemiluminescence and immunosupperssion in 36 patients with AMI,38 cases of patients with angina pectoris（AP）and 30 cases of normal control.Results The peak time of CK-MB mass and activity in AMI patients was exactly the same,but the rise of CK-MB mass ratio（18 times）obviously higher than CK-MB activity（7times）;CK-MB mass and activity in AMI patients were significantly higher than that of AP group and normal control group,the difference was statistically significant（P〈0.01）.CK-MB activity in AP group was higher than that of normal control group,the difference was statistically significant（P〈0.01）,the difference of CK-MB mass in AP group and normal control group was not statistically significant（P〈0.05）.Conclusion CK-MB mass and activity in the early diagnosis of AMI are very sensitive,but the determination of CK-MB mass in the fight against interference factors was significantly better than CK-MB activity.