血清胆红素水平与冠脉支架植入术后再狭窄的相关性研究

The relationship between serum bilirubin and intracoronary in-stent restenosis

目的探讨冠状动脉(冠脉)内药物涂层支架植入术后支架内再狭窄与血清胆红素的相关性。方法对82例成功行经皮冠脉药物涂层支架植入术的患者术后再次行冠脉造影,以原病变冠脉直径狭窄程度≥50%为支架内再狭窄,按有无再狭窄分为再狭窄组16例和非再狭窄组66例。比较2组胆红素等临床血清学指标及临床资料,探讨血清胆红素是否与支架内再狭窄有关。结果再狭窄组总胆红素水平低于非再狭窄组,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示空腹血糖、尿酸是再狭窄的危险因素,总胆红素是再狭窄的保护因素(P<0.05)。结论血清总胆红素与冠脉支架内再狭窄密切相关,高水平总胆红素可能降低冠脉支架内再狭窄的发生。

Objective To explore the relationship between serum bilirubin and coronary in-stent restenosis after drug-eluting stent implantation.Methods The study enrolled 82 patients who underwent drug-eluting stent implantation and accepted coronary angiography.The vascular＇s diameter stenosis ≥50% was used as a definition of restenosis.According to restenosis,the patients were divided into restenosis group（16 cases） and non restenosis group（66 cases）.bilirubin in clinical serology and clinical data were compared,and the relationship between serum bilirubin level and coronary in-stent restenosis was analyzed.Results Compared to nonrestenosis group,serum total bilirubin level was lower in restenosis group（P0.05）.As a result of multivariate logistic regression analysis,diabetes and urine acid were risk factors contributed to restenosis,while total serum bilirubin was a protecting factor to restenosis（P0.05）.Conclusion Serum bilirubin is closely correlated with in-stent restenosis after drug-eluting stent implantation in coronary artery,and high serum bilirubin level may reduce the occurs of restenosis.