胆汁反流性胃炎与幽门螺杆菌的正相关性临床研究

The relationship between the bile reflux gastritis and helicoacter pylori

目的探讨幽门螺杆菌(Hp)感染与胆汁反流性胃炎之间是否存在正相关性。方法将94例胆汁反流性胃炎合并Hp感染患者随机分为试验组和对照组各47例。对照组给予莫沙比利+埃索美拉唑进行治疗;试验组在对照组治疗基础上加用克拉霉素和阿莫西林进行根除Hp治疗。观察并比较2组临床疗效及Hp根除率。结果试验组临床总有效率、Hp根除率分别为82.98%、87.23%,高于对照组的42.55%、14.89%,差异均有统计学意义(P<0.05)。结论 Hp感染是引起胆汁反流性胃炎的重要因素之一,对于胆汁反流性胃炎合并Hp感染,应首先考虑进行根除Hp的治疗。

Objective To explore the relationship between the bile reflux gastritis and helicoacter pylori（Hp）.Methods 94 patients with bile reflux gastritis combined with Hp infection in patients were divided into control and experimental group（47 in each） and control group received esomeprazole,mosapride;The experimental group based on the use Amo Xilin and clarithromycin for eradication of Hp therapy.Results The overall improvement rate was 78.45 percent,while the control group was 54.33%.Experimental group,negative conversion rate of 87.23% Hp,the control group was 14.56%.The difference between the two groups was significant.Clinical efficacy and Hp eradication rate was compared.Conclusion Hp infection is a important factor,for bile reflux,on bile reflux gastritis combined treatment of Hp infection,should first consider the eradication of Hp.