摘要
目的探讨不同他汀类药物对急性心肌梗死患者氨基末端脑钠肽前体(NT-proBNP)的影响。方法将100例急性心肌梗死患者随机分为A、B两组,A组为口服阿托伐他汀组(40mg/d,50例),B组为口服瑞舒伐他汀组(20mg/d,50例),分别在入院后及服药后4周测定两组患者NT-proBNP水平,并进行比较。结果两组治疗后血NT-proBNP水平均低于治疗前,治疗前后比较差异有统计学意义(P<0.05);治疗前后两组间分别比较,差异无统计学意义(P>0.05)。结论两种他汀类药物强化治疗均可在短期内降低AMI患者的血NT-proBNP的水平。
Objective To investigate the effects of different statins on serum levels of NT-proBNP in patients with AMI.Methods 100 consecutive patients with AMI were randomly divided into two groups.50 Patients in group A were given oral atorvastatin 40 mg once daily and 50 patients in group B were given oral rosuvastatin 20 mg once daily.The NT-proBNP were measured after be in hospital and 4 week after therapy.The difference in NT-proBNP was compared between the two groups and subset groups.Results The levels of NT-proBNP in the patients of the two groups after 4 week were significantly lower than those before therapy（P0.05）.The changes of NT-proBNP were not significantly different between the two groups（P0.05）.Conclusion The intensification therapy of two kinds of statins makes NT-proBNP levels drop in the short term.
出处
《临床合理用药杂志》
2012年第12期9-10,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
心肌梗死
阿托伐他汀
瑞舒伐他汀
氨基末端脑钠肽前体
Myocardial infarction
Atorvastatin
Rosuvastatin
N-terminal pro-brain natriuretic peptide
