队列研究与正常儿童平均得分相比，胎儿期在子宫内暴露于丙戊酸钠的学龄儿童语言能力得分偏低
Cohort study School-aged children who were exposed to sodium valproate in utero have impaired language scores when compared with a population mean score
摘要
背景连续服用抗癫痫药物（AEDs）对多数患有癫痫症的孕妇而言是必要的。胎儿在子宫中暴露在抗癫痫药物对其身体的负面影响已经被广泛引证，其中风险最大的是暴露于丙戊酸钠（VPA）。
出处
《英国医学杂志中文版》
2012年第2期114-115,共2页
The BMJ Chinese Edition
参考文献5
-
1Meador K, Reynolds MW, Crem S, et al. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 2008 ;81:1-13.
-
2Meador K J, Baker GA, Browning N, et al. Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age. Brain 2011 ; 134 : 396404.
-
3Bromley RL, Mawer G, Love J, et al. Early cognitive development in children born to women with epilepsy: a prospective report. Epilepsia 2010 ; 51 : 2058 -65.
-
4Nadebaum C, Anderson V, Vajda F, et al. The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy. J Int Neuropsychol Soc 2011 ; 17 : 133-42.
-
5Adab N, Kini U, Vinten J, et al.. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatr 2004 ;75 : 1575-83.
-
1罗志刚,邱传亮,谢平.RGD序列模拟物合成研究进展[J].解放军药学学报,2005,21(2):129-132. 被引量：1
-
2接受抗癫痫药治疗的女性可哺乳[J].广州医科大学学报,2014,42(5):86-86.
-
3药物警戒快讯[J].中国药物警戒,2015,12(1):61-64.
-
4金伟秋（摘）.FDA收到Cellcept致先天性畸形报告[J].国外药讯,2008(11):29-30.
-
5曾方,黄霞英,伍思琪.人胎儿期睾丸位置的观察[J].广东药学院学报,1991,7(2):67-67.
-
6美国FDA警告子宫内暴露丙戊酸钠致小儿认知发展障碍的风险[J].中国执业药师,2011,8(10):19-19.
-
7于国睿.浅谈妊娠期的合理用药[J].基层医学论坛,2007,11(S1):88-88.
-
8于涛,逯晓波,潘亮,刘艳华,肖莎.邻苯二甲酸二(2-乙基己基)酯宫内暴露所致子代雄性大鼠睾丸氧化应激及维生素C的干预作用[J].环境与健康杂志,2011,28(9):775-778. 被引量：5
-
9余方宇,郭建波,牟丹辉.异丙嗪在急性兴奋型酒精中毒中的应用[J].海峡药学,2011,23(5):107-109. 被引量：3
-
10魏圣明,王跃平,邹大卫,舒斯伟,明腾.贯扎法手术治疗先天性膈膨升[J].江西医药,1989,24(2):92-93.
