辽宁城市体检人群代谢综合征与五年累积心血管事件发病风险的关系

Relationship between metabolic syndrome and five-year cumulative onset risk of cardiovascular event among health-examination people in city of Liaoning province

目的:前瞻性研究代谢综合征(MS)与心血管事件发病风险的关系。方法:研究对象来源于中国医科大学附属第一医院,从体检确诊为MS人群中随机抽取300例,2006年～2011年连续随访5年。结果:270例进入本研究,其中男227例,女43例,年龄(56.23±18.15)岁。年龄标化后5年间心血管事件累积发病率为9.88%。基线高敏C反应蛋白(hsCRP)水平作4分层,Logistic回归分析显示:男女两性心血管事件的累积发病率均有随hsCRP水平升高而逐渐增加的趋势(P<0.01),调整基线年龄、高血压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血糖(FBG/PBG)、吸烟和腹部肥胖后,男女两性中hsCRP≥3mg/L者发生心血管事件危险分别是hsCRP<1mg/L者的1.98倍(95%CI:1.15～5.77)和1.95倍(95%CI:1.13～5.39),P<0.01。结论:基线高敏C反应蛋白水平是代谢综合征人群发生心血管事件的独立预测因素,提示慢性炎症在代谢综合征人群心血管事件发生的病理过程中发挥重要作用。

Objective：To prospectively study relationship between metabolic syndrome（MS） and onset risk of cardiovascular event.Methods：Subjects were selected from first affiliated hospital of China Medical University.A total of 300 cases diagnosed as MS were randomly selected from examination peoples,and they were followed up for five years from 2006 to 2011.Results：A total of 270 cases were enrolled in the study,including 227 males and 43 females with age（56.23±18.15） years.After age standardization,cumulative incidence rate of cardiovascular events in five years was 9.88%,the baseline level of high sensitive C reactive protein（hsCRP） was stratified into four layers,Logistic regression analysis show that there were tendency i.e.both in male and female,cumulative incidence rate of cardiovascular events gradually elevate as hsCRP level increase（P0.01）,after adjustments for baseline age,hypertension,low-density lipoprotein cholesterol,high density lipoprotein cholesterol,triglyceride,blood glucose（FBG/PBG）,smoking and abdominal obesity,onset risk of cardiovascular event in male and female with hsCRP ≥3 mg/L were 1.98 times（95%CI： 1.15~5.77） and 1.95 times（95%CI： 1.13~5.39） for those of male and female with hsCRP1 mg/L respectively.Conclusion：Baseline level of hsCRP is an independent predictor of cardiovascular event in people with metabolic syndrome,suggesting that chronic inflammation plays an important role in the pathological process of cardiovascular event in people with metabolic syndrome.