择期冠脉支架置入术对急性心肌梗死患者血清细胞色素C水平的影响

Influence of delayed percutaneous coronary intervention on serum level of cytochrome C in patients with acute myocardial infarction

目的:观察择期冠状动脉支架置入术对急性心肌梗死(AMI)患者血清细胞色素C(Cyt C)水平的影响。方法:入选AMI并于梗死后10-14d行冠状动脉支架置入术的患者30例作为AMI组;另选择经冠脉造影排除冠心病(CHD)的患者30例作为非CHD对照组,采用酶联免疫吸附(ELISA)方法测定患者在冠状动脉支架置入术前,术后48h、72h血清Cyt C浓度。结果:1.冠脉支架置入术前AMI组血清Cyt C水平显著高于非CHD对照组[(1.18±0.71)ng/ml比(0.25±0.03)ng/ml,P<0.01];2.冠状动脉支架置入术后48h、72h血清Cyt C水平[(0.68±0.29)ng/ml、(0.66±0.25)ng/ml]显著低于冠状动脉支架置入术前(P<0.01)。结论:择期冠脉支架置入术能改善急性心肌梗死患者心肌细胞的凋亡。

Objective： To observe influence of delayed percutaneous coronary intervention（PCI） on serum level of cytochrome C（Cyt C） in patients with acute myocardial infarction（AMI）.Methods：A total of 30 AMI patients undergoing PCI on 10~14d after myocardial infarction were regard as AMI group;another 30 patients excluded coronary heart disease（CHD） by coronary angiography were treated as non-CHD control group.Enzyme linked immunosorbent assay（ELISA） was used to measure serum concentration of Cyt C before,48h and 72h after PCI.Results：1.Serum level of Cyt C in AMI group before PCI was significantly higher than that of non-CHD control group [（1.18±0.71） ng/ml vs.（0.25±0.03） ng/ml,P0.01];2.serum levels of Cyt C in AMI group on 48h and 72h after PCI [（0.68±0.29） ng/ml,（0.66±0.25） ng/ml]were significantly lower than that of before PCI（P0.01）.Conclusion： Delayed percutaneous coronary intervention can improve apoptosis of myocardial cells in patients with acute myocardial infarction.