芪苈强心胶囊治疗慢性心力衰竭疗效观察

Therapeutic effects of Qili capsule on chronic heart failure

目的:探讨芪苈强心胶囊治疗慢性心力衰竭(CHF)的疗效。方法:69例CHF患者被随机分为观察组(35例,在常规西药基础上加芪苈强心胶囊治疗8周)和常规治疗组(34例,接受常规西药治疗8周)。治疗前后观察患者临床症状,6min步行距离,检测血清B型利钠肽(BNP)水平和左室射血分数(LVEF)。结果:(1)治疗后两组患者BNP水平均明显下降,LVEF均明显提高(P<0.05);与常规治疗组比较,观察组临床症状明显改善,6min步行距离明显增加[(368.36±38.14)m比(456.22±38.25)m],LVEF[(0.403±0.081)比(0.446±0.074)]进一步提高;血BNP[(456.43±35.94)pg/ml比(388.28±30.36)pg/ml]水平进一步下降,P均<0.05;(2)观察组显效率及总有效率均明显高于常规治疗组(37.1%比26.5%,88.6%比82.4%,P<0.05)。结论:芪苈强心胶囊可明显改善心功能,降低血B型利钠肽水平,提高疗效。

Objective： To study therapeutic effects of Qili capsule in patients with chronic heart failure（CHF）.Methods：A total of 69 CHF patients were randomly divided into observation group（n=35,received Qili capsule based on routine western medicinal treatment for eight weeks） and routine treatment group（n=34,received routine western medicinal treatment for eight weeks）.Improvements of clinical symptoms and 6-min walking distance were observed,serum level of B type natriuretic peptide（BNP）and left ventricular ejection fraction（LVEF） were measured before and after treatment.Results：（1） After treatment,there were significant decrease in BNP level and significant increase in LVEF in both groups（P0.05 all）;compared with routine treatment group,there were clinical symptoms＇ significant improvement,significant increase of 6-min walking distance [（368.36 ±38.14） m vs.（456.22±38.25） m]and LVEF [（0.403±0.081） vs.（0.446±0.074）],and significant decrease in plasma level of BNP [（456.43±35.94） pg/ml vs.（388.28±30.36） pg/ml]in observation group,P0.05 all;（2） Markedly effective rate and total effective rate of observation group were significantly higher than those of routine treatment group（37.1% vs.26.5%,88.6% vs.82.4%,P0.05 both）.Conclusion： Qili capsule can significantly improve heart function,decrease BNP,increase therapeutic effects in patients with chronic heart failure.