IQGAP1在哈萨克族食管癌组织中的表达及意义

The expression and clinical significance of IQGAP1 in esophageal cancer of Kazaks

目的:检测IQ结构域三磷酸鸟苷合酶-激活蛋白1(IQ domain GTPase-activating protein 1,IQGAP1)在哈萨克族食管癌组织中的表达,分析其与临床病理参数的相关性。方法:采用逆转录PCR(reverse transcription polymerase chain reaction,RTPCR)检测48例哈萨克族食管癌切除标本中癌组织与远端无癌组织中IQGAP1 mRNA表达水平,并分析其与临床病理指标的关系。结果:癌组织中IQGAP1 mRNA表达阳性率(50%)高于其远端无癌组织(21%),其差异具有统计学意义(P<0.05);但IQGAP1 mRNA的表达与癌组织分化程度、病理分期及有无淋巴结转移均无相关性(P>0.05)。结论:IQGAP1基因的表达可能与哈萨克族食管癌的发生有关。

OBJECTIVE：To investigate the expression of IQGAP1 in esophageal cancer tissues and its relationship between their expressions and the clinical pathological features in Kazaks.METHODS：The mRNA expression level of IQGAP1 in 48 Kazak＇s esophageal cancer specimens were measured by RT-PCR.The relationship between clinical pathologic features and expressions of IQGAP1mRNA level was analyzed.RESULTS：The expression of IQGAP1 mRNA in cancer tissues was（50%） significantly higher than that of normal tissues（P0.05）.However,the expression level of IQGAP1 mRNA was not significantly related to the degree of differentiation,depth of invasion and lymph node metastasis.CONCLUSION：IQGAP1 gene expression may be related to the development of esophageal cancer with Kazak.