虎眼万年青的化学成分

STUDIES ON THE CHEMICAL CONSTITUENTS FROM ORNITHOGAUM CAUDATUM AIT

目的：研究栽培于长白山区的虎眼万年青Ｏｒｎｉｔｈｏｇａｌｕｍ ｃａｕｄａｔｕｍ Ａｉｔ 全草的化学成分。方法：用各种色谱技术进行分离和纯化，用ＥＳＩＭＳ，ＩＲ，１ＨＮＭＲ，１３ＣＮＭＲ，ＤＥＰＴ，１Ｈ１ＨＣＯＳＹ，１Ｈ１３ＣＣＯＳＹ，ＨＭＢＣ和ＮＯＥＳＹ 等波谱数据分析鉴定结构。结果：从虎眼万年青全草中分离得到３ 个化合物，其中化合物Ｉ为新化合物，其结构鉴定为（２５Ｓ，２３ Ｓ，２４ Ｓ）螺甾Δ５（６）烯１β，３β，２３ ，２４四醇１ＯαＬ吡喃鼠李糖基（１ →２） ［βＤ吡喃木糖基（１ →３）］αＬ吡喃阿拉伯糖苷（Ｉ），另外２ 个已知化合物为海柯皂苷元３Ｏ｛βＤ吡喃葡糖基（１ →２）［βＤ吡喃木糖基（１ →３）］βＤ吡喃葡糖基（１ →４）βＤ吡喃半乳糖苷｝（ＩＩ）和β谷甾醇（ＩＩＩ）。结论：化合物Ｉ为新化合物，命名为虎眼万年青苷Ａ，化合物ＩＩ和ＩＩＩ是首次从该植物中分得的已知化合物。

AIM: To investigate the chemical constituents of the whole plant of Ornithogalum caudatum Ait. METHODS: Various chromatographic techniques were used to separate the chemical constituents. ESIMS, IR, 1HNMR, 13 CNMR, DEPT, 1H 1H COSY, 1H 13 C COSY, HMBC and NOESY were used to determine the structure of the isolated constituents. RESULTS: Three compounds were isolated from the whole plant of Ornithogalum caudatum Ait. They were identified as (25 S ,23 S ,24 S ) spirosta Δ 5 ene 1β,3β,23,24 tetral 1 O α L rhamnopyranosyl(1→2) [β D xylopyranosyl(1→3)] α L arabinopyranoside(I); Hecogenin 3 O [β D glucopyranosyl (1→2) [β D xylopyranosyl (1→3)] β D glucopyranosyl (1→4) β D galactopyranoside](II) and β sitosterol (III). CONCLUSION: Compound 1 is a new steroidal saponin and was given the name caudaside A. Compounds II and III were obtained from this plant for the first time.