硫酸氢氯吡格雷联合阿托伐他汀钙治疗老年不稳定性心绞痛的疗效

Effectiveness of Combined Clopidogrel Hydrogen Sulphate and Atorvastatin Calcium Treatment in Elderly Patients with Unstable Angina

目的探讨硫酸氢氯吡格雷联合阿托伐他汀钙治疗老年不稳定性心绞痛(UA)的临床效果。方法将90例UA老年患者按随机数字表法分为观察组和对照组,每组45例。2组均接受常规药物治疗。在此基础上对照组给予辛伐他汀片20mg,每晚口服。观察组给予阿托伐他汀钙胶囊10mg,每晚口服;硫酸氢氯吡格雷片75mg,早上口服。2组患者均连续用药2周后进行疗效评定。结果观察组患者治疗后心绞痛发作频次、持续时间、胆固醇水平均低于对照组(均P<0.05)。观察组总有效率为95.56%,对照组为71.11%,2组比较差异有统计学意义(P<0.05)。2组在治疗过程中均未见明显不良治疗反应,无不良事件发生。结论硫酸氢氯吡格雷联合阿托伐他汀钙治疗老年不稳定性心绞痛效果好,安全性高。

Objective To investigate the effect of combined treatment with clopidogrel hydrogen sulphate and atorvastatin calcium on unstable angina（UA） in elderly patients.Methods Ninety elderly patients with UA were divided into observation group and control group,with 45 patients in each group.All patients received conventional drug therapy.On this basis,control group was given night oral atorvastatin calcium（20 mg） and observation group was given combined treatment with morning oral clopidogrel hydrogen sulphate（75 mg） and night oral atorvastatin calcium（10 mg）.The efficacy was evaluated after continuous medication for 2 weeks.Results Compared with control group,UA attack frequency,duration and cholesterin levels significantly decreased in observation group（all P0.05）.Moreover,the total effective rate in observation group was obviously higher than that in control group（95.56% vs 71.11%,P0.05）.No significant adverse reactions were found in both groups.Conclusion The combined treatment with clopidogrel hydrogen sulphate and atorvastatin calcium is effective and safe for UA in elderly patients.