大肠癌组织胃泌素与增殖细胞核抗原表达的关系

The relationship between gastrin and PCNA expression in colorectal cancer tissue

目的 :研究大肠癌组织胃泌素与增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)表达的关系 ,以探讨胃泌素对大肠癌的促增殖作用。方法 :采用免疫组化法检测 4 8例大肠癌患者癌组织及癌旁粘膜胃泌素和PCNA的表达。结果 :大肠癌组织胃泌素阳性率为 3 9 5 % ,高分化腺癌明显高于低分化和粘液腺癌 (P <0 0 5 )。癌组织的PCNA LⅠ显著高于癌旁粘膜和正常粘膜 (P <0 0 1) ,Dukes C期和D期显著高于A期 (P <0 0 5 )。胃泌素阳性组癌组织PCNA LⅠ为 63 16± 15 14 ,胃泌素阴性组为 4 7 4 1± 13 0 4 ,两者差异显著 (P <0 0 1)。结论 :部分大肠癌细胞可能通过自分泌方式产生胃泌素 。

Objective:To study the relationship between gastrin and proliferating cell nuclear antigen (PCNA)expression in colorectal cancer tissue and growth promoting effect of gastrin. Methods:The gastrin and PCNA expression in 48 cases of colorectal cancer tissue and cancer adjacent mucosa were detected with immunohistochemistry techniques. Results:The positive rate of gastrin in colorectal cancerous tissue was 39 58%,the well differentiated adenocarcinoma was higher than the poorly differentiated and mucinous adenocarcinoma( P < 0 05).The PCNA LⅠin colorectal cancer tissue was higher than that in cancer adjacent and normal mucosa( P < 0 01),the PCNA LⅠin DukesC and D stage was higher than that in A stage( P < 0 05).The PCNA LⅠin the group of gastrin positive expression was 63 16±15 41,obviously higher than that in the group of gastrin negative expression(47 41±13 04). Conclusions:Some of colorectal cancer cells secreted gastrin through autocrine and stimulated the cancer cells proliferation.