肿瘤相关巨噬细胞与肝癌的研究进展

Research progression of tumor-associated macrophage and hepa- tocellular carcinoma

慢性炎性介质反应与肿瘤发生也发展密切相关，肿瘤相关巨噬细胞作为肿瘤免疫微环境中最丰富的免疫细胞，在连接慢性炎性介质反应与肿瘤之间发挥重要的桥梁作用。大多数肿瘤相关巨噬细胞表型和功能倾向于M2型巨噬细胞，并被认为是肿瘤患者预后不良的重要标志。我国肝癌患者大多伴有长期慢性病毒感染，肝脏中大量巨噬细胞在长期慢性炎性介质反应浸润刺激下可通过多种途径促进肝癌发生、发展。本文就肿瘤相关巨噬细胞与肝癌发生、发展作一综述。

Chronic inflammation has been demonstrated closely related to the tumor progression. Tumor- associated macrophage, as the most abundant inmmne ceils in the tumor microenvironment, is a key element that links inflammation and cancer. Recently, studies found that the phenomenon and function of tumor-as- sociated macrophage almost tend to M2 type maerophage. As an important indicator, tumor-associated rnac- rophage usually predicts the poor progress with the cancer development. In China, Most of patients with hep- atocellular carcinoma are associated with chronic viral infection, A large number of macrophages in the liver infihrated in chronic inflammation, which are differentiated by variety of mechanisms under the chronic in- flammatory stimulation, promote the development of liver cancer. In this paper, we will review the tumor- as- sociated macrophages and the development of liver cancer.