男性炎症性肠病患者的性功能障碍

Male sexual dysfunction in inflammatory bowel disease

男性性功能障碍与治疗炎症性肠病(inflammatory bowel disease,IBD)的药物、IBD伴发的抑郁情绪及治疗抑郁的药物以及直肠结肠切除术合并回肠带肛管吻合术(IPAA)等相关。在治疗炎症性肠病的药物中,氨甲喋呤及柳氮磺胺吡啶是最有可能导致勃起功能障碍的。抑郁是引起性功能障碍最重要的决定性因素,治疗抑郁的药物也可能引发男性性功能障碍。IPAA可能会引起男性性功能障碍,但是大部分患者可被西地那非纠正。本文为临床医生治疗男性IBD患者的性功能障碍提供参考。

Male sexual function is related with some drugs used to treat IBD,depression accompanied with active IBD and proctocolectomy combined with ileal pouch anal anastomosis（IPAA）.Methotrexate and Salazosulfapyridine are most likely to cause erectile dysfunction（ED） in the medications to treat IBD.Depression is the most important determinant of reduced sexual function and antidepressants may cause male sexual dysfunction.IPAA can lead to male sexual dysfunction while it can be treated successfully with sildenafil in most cases.This review provides a reference to treat male sexual dysfunction in patients with inflammatory bowel disease.