重组α-2b干扰素治疗儿童慢性乙型肝炎疗效观察

Effect of recombinant α-2b interferon in children with chronic virus B hepatitis

目的 观察基因重组α - 2b干扰素治疗儿童慢性乙型肝炎疗效。方法 将 10 8例慢性乙型肝炎患儿分为治疗组 78例、对照组 30例 ,治疗组给予α - 2b干扰素治疗 ,疗程半年 ,治疗后观察肝功能及HBV标志。结果 治疗组HBeAg及HBV -DNA转阴率分别为 39 7%和 38 5 % ,均显著高于对照组 (P <0 0 1) ,丙氨酸转氨酶 (ALT)复常率、HBsAg转阴率分别为 96 2 %、5 1% ,与对照组无显著性差异 (P >0 0 5 )。结论 基因重组α - 2b干扰素是治疗小儿慢性乙型肝炎的有效药物 ,其疗效与ALT水平。

Objective To observe the effect of recombinant α-2b interferon on children's hepatitis B.Methods 78 cases of children chronic hepatitis B were treated with α-2b interferon add-on,and 30 cases were treated with routine therapy as controls.The courses of treatment was six monthes.Serum alanine transaminase(ALT) and HBVmark(HBVM) were estimated.Results The serum conversion rates of HBeAg and HBVDNA treated with α-2b interferon were 39 7% and 38 5% respectively,which were significantly higher than those of controls(P<0 01),the conversion rates of ALT and HBsAg were 96 2%,and 5 1% respectively ,which had no significant difference than those of controls(P>0 05).Conclusion Recombinant α-2b interferon is effective for treating children chronic HBV hepatitis,the effect is related to ALT and age.