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紫草素对涎腺腺样囊性癌SACC-83增殖和凋亡的影响

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摘要 目的探讨紫草素对人腺样囊性癌SACC-83增殖和凋亡的影响。方法甲基塞唑蓝检测紫草素对SACC-83体外生长抑制作用;吖啶橙-溴化乙锭荧光染色观察细胞形态变化;流式细胞仪测定细胞周期和凋亡率。结果紫草素以剂量和时间依赖的方式抑制SACC-83细胞生长,以剂量依赖的方式使SACC-83细胞周期阻滞在S期,诱导细胞凋亡;染色可见细胞呈明显凋亡特征。结论紫草素对SACC-83细胞具有明显增殖抑制及诱导凋亡作用,且具有浓度和时间依赖性。
出处 《中国医学工程》 2012年第3期74-74,77,共2页 China Medical Engineering
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