脑梗塞患者血浆血栓烷B_2与11-去氢-血栓烷B_2的对比研究

Comparative Studies on Plasma Thromboxane B_2 and 11-dehydrothromboxane B_2 in Patients with Cerebral Infarction

目的 研究脑梗塞患者１１－ 去氢－ 血栓烷Ｂ２（１１－ ＤＨ－ ＴＸＢ２） 与血栓烷Ｂ２（ＴＸＢ２） 对血小板活化程度的敏感特异性。方法 采用酶免疫法、放射免疫法检测４３ 例脑梗塞患者与对照组（１５ 例） 血浆（１１ － ＤＨ－ ＴＸＢ２）浓度，对比两者的敏感特异性，并研究脑梗塞患者１１ － ＤＨ－ ＴＸＢ２ 、ＴＸＢ２ 的改变。结果 患者组血浆１１ － ＤＨ－ＴＸＢ２ 浓度显著高于对照组（ Ｐ＜０ ．００１） ，而ＴＸＢ２ 浓度变化无显著差异（ Ｐ＞ ０．０５） ；其中发病在７２ｈ 内的患者有８１．２５ ％ 血浆１１－ ＤＨ－ ＴＸＢ２ 浓度高于对照组峰值；而ＴＸＢ２ 与对照组有相当的重叠。结论 与ＴＸＢ２ 相比，血浆１１－ ＤＨ－ ＴＸＢ２ 能更特异与敏感地反映体内血小板活化程度，急性期脑梗塞患者体内血小板高度活化。

Objective and methods The plasma concentration of 11-dehydro-thromboxane B 2(11-DH-TXB 2) in 43 patients with acute cerebral infarction (CI),and that in 15 normal controls were assayed.Results The 11-DH-TXB 2 levels in patients (44.38±14.93ng/L) were significantly elevated ( P <0.001),but not those of TXB 2.In 81% of patients who were within 72h of onset,11-DH-TXB 2 levels exceeded the peak value of the controls (39.43ng/L).while the plasma TXB 2 levels in the patient showed a considerable overlap with those in the controls.Conclusions These results suggest that determination of plasma 11-DH-TXB 2 is more sensitive and accurate than the TXB 2 in the evaluating in vivo platelet activation,and platelets are markedly activated in C1 patients.