血浆纤维蛋白原与血浆粘度相关性及其临床意义研究

Study of the Relationship between Plasma Fibrinogen Concentration and Plasma Viscosity and Its Clinical Meaning

目的 探讨血浆纤维蛋白原（ｆｉｂｒｉｎｏｇｅｎ，ＦＧ） 与血浆粘度（ｐｌａｓｍａ ｖｉｓｃｏｓｉｔｙ，ＰＲＶ） 相关性及其临床意义。方法 测定观察组５４３０ 例，正常对照组１５０ 例，缺血性脑中风组（缺血组）１７０ 例的血浆ＦＧ含量和ＰＲＶ，进行相关分析与ｔ 检验。结果 观察组ＰＲＶ 与ＦＧ 含量的相关系数ｒ＝ ０ ．６３７ ，Ｐ＜ ０．００１。血浆ＦＧ 含量：对照组２ ．８８ ±１ ．０８ｇ／Ｌ，缺血组３．９６±１ ．７６ｇ／Ｌ；ＰＲＶ∶对照组１ ．６９ ±０．１２ｃｐ，缺血组１ ．７８ ±０ ．２２ｃｐ 。结论 ＰＲＶ 随ＦＧ含量上升而升高，两者呈正相关；ＦＧ对ＰＲＶ 影响的大小取决于ＦＧ的含量与活性；缺血组ＰＲＶ 与ＦＧ 含量较对照组显著升高（ Ｐ＜０ ．００１） ，提示血浆ＦＧ 含量升高为缺血性脑中风的独立危险因素之一。

Object To investigate the relationship between plasma fibrinogen (FG) concentration and plasma viscosity (PRV),and discuss its clinical meaning.Method FG and PRV in 5430 general subjects,150 adults in the control group and 170 patients in ischcmic cerebral stroke group (ischemic,group) were examined for statistical analysis.Result For correlation coefficient between general subjects plasma FG concentration and PRV ( r =0.637, P <0.001).FG concentration and PRV that had been examined are 2.88±1.08g/L,1.69±0.12cp in cortrol group and 3.96±1.76g/L,1.78± 0.22 cp in ischemic group respectively.Conclusion PRV ascends with the increase of FG concentration and there is positive relation between them,the effect of FG on PRV depends on both in the concentration and activation.Plasma FG conentration and PRV in ischemic group are higher than that in the cortrol group significantly ( P <0.001).Increased plasma FG concentration may be one of the independent risk factors for ischemic cerebral stroke.