喹诺酮类抗菌药物的研究XV.6-氯-1-(2,4-二氟苯基)-7-(1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸及其类似物的合成与抗菌作用

Study on Quinolonecarboxylic Acids as Antibacterial Agents XV. Synthesis and Antibacterial Activity of 1- (2 ,4- Difluoro- phenyl) - 6- chloro- 7- (1- piperazinyl) - 1,4- dihydro- 4 - oxo- 3- quinoline carboxylic Acid and Analogues

合成了12个6-氯-1-(2,4-二氟苯基)-7-(1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸及其类似物,并测定了它们的体外抗菌活性。结果表明,其中4Ab对金葡菌-9的活性是环丙沙星的12倍、诺氟沙星的50倍。

Twelve 1 - ( 2 ,4 - difluorophenyl or 4 - fluorophenyl ) - 6- chloro- 7- ( 1 - nitrogenous heterocyclic) - 1 ,4 - dihydro- 4 - oxo- 3- quinolinecarboxylic acids were synthesized .The ciprofloxacin and norfloxacin were included for comparative purposes.The results of the in vitro antibacterial activities of these compounds showed that4 Ab was1 2 and5 0 times more active than ciprofloxacin and5 0 norfloxacin respectively against S.aureus- 9.