摘要
合成了12个6-氯-1-(2,4-二氟苯基)-7-(1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸及其类似物,并测定了它们的体外抗菌活性。结果表明,其中4Ab对金葡菌-9的活性是环丙沙星的12倍、诺氟沙星的50倍。
Twelve 1 - ( 2 ,4 - difluorophenyl or 4 - fluorophenyl ) - 6- chloro- 7- ( 1 - nitrogenous heterocyclic) - 1 ,4 - dihydro- 4 - oxo- 3- quinolinecarboxylic acids were synthesized .The ciprofloxacin and norfloxacin were included for comparative purposes.The results of the in vitro antibacterial activities of these compounds showed that4 Ab was1 2 and5 0 times more active than ciprofloxacin and5 0 norfloxacin respectively against S.aureus- 9.
出处
《中国医药工业杂志》
CSCD
北大核心
2000年第1期25-28,共4页
Chinese Journal of Pharmaceuticals
关键词
喹诺酮酸
合成
抗菌活性
quinolonecarboxylic acid
synthesis
antibacterial activity