慢性丙型肝炎患者红细胞天然免疫粘附功能的变化及意义

Changes and significance of red cell nature immune adhesion function(RNIAF) in patients with chronic hepatitis C

目的:研究慢性丙型肝炎患者红细胞天然免疫粘附功能(RNIAF)的变化,探讨其临床意义。方法:选择血清HCV RNA大于103copies/ml的38例肝功能正常、40例肝功能异常及26例肝炎后肝硬化的患者作为研究对象,采用红细胞天然免疫粘附肿瘤细胞功能实验,对104例研究对象及30例正常人的RNIAF进行测定,并检测CHE、PTA数值。结果:肝功能正常的慢性丙型肝炎患者RNIAF与正常人群组比较无显著差异(P>0.05)。肝功能异常的慢性丙型肝炎患者RNIAF低于肝功正常的患者及正常人群(P<0.05)。肝硬化患者RNIAF均显著低于肝功正常的患者及正常人群(P<0.01)。结论:慢性丙型肝炎患者RNIAF的变化与其疾病的不同时期及病情的严重程度密切相关,可作为判断该类患者病情变化的重要指标。

Objective：To study the changes and significance of red cell nature immune adhesion function（RNIAF） in patients with chronic hepatitis C.Methods：The assay of red cell nature immune-adhering tumor cell was performed in 30 healthy individuals and 104 patients with HCV RNA more than 103 copies/ml in serum.In those patients,38 cases were with normal hepatic function,40 cases were abnormal hepatic function and 26 cases were cirrhosis patients.Results：The RNIAF of patients with normal hepatic function was not obviously different from that of healthy individuals（P0.05）.The RNIAF of patients with abnormal hepatic function was significantly lower than that with normal hepatic function and healthy individuals（P0.05）.The RNIAF of cirrhosis patients was obviously lower than that with normal hepatic function and healthy individuals（P0.01）.Conclusion：There was a good relationship between the variety of RNIAF and the severity of diseases in patients with chronic hepatitis C.It is important to assay the RNIAF in these patients to evaluate the variety of diseases.