5Jones NR.The current and future impact of antimicrobial resistance a mong nosocomail bacterial pathogens[J].Diagn Microbiol Infect Dis,1992;15:35.
6Coffey TJ,Daniels M,Mcdougel LK,et al.Genetic analysis of clinical isolated of Streptococcus pneumoniae with highlevel resistance to expanded-spectrum cephalosporins[J].Antimicrobial Agents Chemother,1995;39(6):1306-1313.
7Yamane A,Nadano H,Asahi Y,et al.Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B of peni-cillin-resisitant Streptococcus pneumoniae[J].Antimicrobial Agent and Chemotherapy,1996;40(5):1257.
8Asahi Y,Takeuchi Y,Ubudata K.Diversity of substitution within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X ephalosporinresistant Streptococcus pneumoniae isolates[J].AntimicrobialAgent and motherapy,1999;43(5):1252.
9Yokoyama K,Doi Y,Yamane K,et al.Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa[J].Lancet,2003;362(9399):1888-1893.
10Leclercq R,Courvalin P.Resistance to macrolides and relatedantibiotics in Streptococcus pneumoniae[J].Antimicrob Agents Chenmother,2002;46(9):2727-2734.
