热应激蛋白70抗体与高血压关系初探

Preliminary study on relationship between antibody against heat streess protein 70 and hypertension

目的 探讨热应激蛋白 70 (HSP70 )抗体与高血压之间的关系。方法 用Westernblot免疫印迹法检测高血压组和非高血压组血清HSP70抗体水平。采用logistic回归分析技术 ,分析HSP70抗体与高血压之间的关系。结果 在排除高血压公认的影响因素 (年龄、性别、工龄、体块指数等 )以及工种的影响后 ,高血压组 ( 160 95mmHg为标准 ,1mmHg =0 13 3kPa)血清HSP70抗体水平明显高于对照组 ;以 14 0 90mmHg为标准 ,高血压与HSP70抗体仍存在较强的联系 ,但联系强度不及原标准显著。结论 HSP70抗体有可能作为HSP70介导某些环境应激引起高血压的血清学标志物或其本身参与了高血压的形成过程。

Objective Topreliminarilyexploretherelationshipbetweenmainantibodyagainstheatstress protein 70 (anti HSP70 )andhypertension .Methods Serumanti HSP70wasdeterminedwithWesternblotting techniqueinhypertensiveandnormotensivegroups .Logisticregressionmodelwasusedtoanalyzetherelationship betweenanti HSP70andhypertension .Results Itwasfoundthatlevelofantibodyagainstthemainheatshock protein 70wassignificantlyhigherinpatientswithhypertension (basedoncriteriaof160 95mmHg ,1mmHg = 0 13 3kPa)thanincontrols ,afteradjustmentforthegenerallyrecognizedriskfactorsforhypertension (suchas age ,sex ,lengthofemployment,bodymassindex ,job ,etal.) .Therestillwasstrongerassociationbetweenanti HSP70andhypertension (basedoncriteriaof14 0 90mmHg) ,butitsstrengthofassociationwasweakerthanthe former.Conclusions Anti HSP70maypotentiallyserveasaserumbiomarkertoassesshypertension ,oranti HSP70itselfmaybeinvolvedinthedevelopmentofhypertension .