傣药“雅解沙把”对醉酒小鼠平衡失调的影响

Effect of Yajieshaba on the Dysequilibrium Alcoholism Mice

目的:观察"雅解沙把"对小鼠醉酒平衡失调的改善作用。方法:采用转棒法和爬杆法建立小鼠醉酒平衡失调模型,观察"雅解沙把"对模型小鼠转棒时间、转棒圈数、爬杆时间及爬杆时行为学等级评分的影响。结果:小鼠以15mL/kg.bw的容量灌胃给予56°酒精可造成平衡失调,"雅解沙把"3.51g生药/kg剂量灌胃给药,能明显延长小鼠在转棒上的停留时间,增加滚棒圈数;能不同程度降低酒后30,60,90min爬杆行为障碍的评分等级。结论:"雅解沙把"能明显改善醉酒小鼠的平衡失调状态。

Objective： To observe the improved effect of YaJieShaBa on the dysequilibrium alcoholism mice. Methods： To build a model of dysequilibrium of alcoholism mice using roll bar and climbing pole methods. The roll bar time and the number of turns were observed while the climbing pole time and behavioral rating scores during climbing were recorded and evaluated. Results： Mice with 15mL/kg. bw 56~ alcohol for dysequilibrium were accepted 3.51 g crude drug/kg by intragastric administration. The roll bar time and the number of turns were significantly improved, and climbing pole behavior disorder rating scores were reduced in different degrees after drinking 30, 60, 90min. Conclusions： YaJieShaBa can significantly improve the state of behavior in mice with dysequilibrium.