胰腺癌细胞中AKR1B10表达对溶瘤腺病毒潜能的影响

Effect of AKR1B10 in Pancreatic Cancer Cells on the Potency of Oncolytic Adenovirus

胰腺癌细胞PaTu8988T对溶肿瘤腺病毒Ad5敏感度高于PaTu8988S,可能是因为后者AKR1B10高表达所致。PaTu8988T-AKR1B10稳定细胞系AKR1B10高表达,对Ad5的敏感性也降低了。

The sensitivity of pancreatic cancer cells PaTu8988T to adenovirus Ad5 is more than PaTu8988S,probably because of the high AKR1B10 expression in latter.PaTu8988T-AKR1B10 stable cell lines AKR1B10 expression is high and the sensitivity to Ad5 also is reduced.