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COX3对肿瘤作用机制的研究进展 被引量：3

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摘要 环氧化酶(Cyclooxygenase,COX)是合成前列腺素过程中的重要限速酶,维持机体的各种生命过程,并引起多种疾病发生与发展;早期发现其有两个同工酶(COX1和COX2),2002年又发现新的同工酶,即COX3。近年来研究表明,COX3可能成为解热镇痛药的新靶点,在特定情况下还参与细胞凋亡,有文献报告其在肿瘤的形成与发展、转移中也扮演着一定的角色.。
作者 周肖 程爱兰 甘润良
机构地区 南华大学肿瘤研究所
出处 《求医问药（下半月刊）》 2012年第2期530-530,F0003,共2页 Seek Medical and Ask The Medicine
关键词 环氧合酶 COX3 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献18

  • 1Mauro A,Lipari L,Leone A. Expression of cyclooxygenase-1and cyclooxygenase-2 in normal and pathological human oral mucosa[J].Folia Histochemica et Cytobiologica,2010,(04):555-563.
  • 2Jung YW,Kim SW,Kim S. Prevalence and clinical relevance of cyclooxygenase-1 and 2 expression in stage ⅡB cervical adenocarcinoma[J].European Journal of Obstetrics & Gynecology and Reproductive Biology,2010,(01):62-66.
  • 3Pires I,Garcia A,Prada J. COX-1 and COX-2 expression in canine cutaneous,oral and ocular melanocytic tumours[J].Journal of Comparative Pathology,2010,(2-3):142-149.doi:10.1016/j.jcpa.2010.01.016.
  • 4SimmonsD L,BottingRM,Robertson PM. Induction of an acetam inophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid an tiinflammatory drugs[J].ProcNatlAcad SciU SA,1999,(06):3275-3280.
  • 5Chandrasekharan NV,Dai H,Roos KL. COX-3,a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs:cloning,structure,and expression[J].Proceedings of The National Academy of Sciences(Usa),2002,(21):13926-13931.doi:10.1073/pnas.162468699.
  • 6Warner TD,Vojnovic I,Giuliano F. Cyclooxygenases 1,2,and 3 and the Production of Prostaglandin 12:Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues[J].Journal of Pharmacology and Experimental Therapeutics,2004.642-647.doi:10.1016/j.joms.2010.11.046.
  • 7Vogiagis D,Brown W,Glare EM. Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugsshow altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA express levels[J].Carcinogenesis,2001,(06):869-874.doi:10.1093/carcin/22.6.869.
  • 8Willoughby D,Moore A,Colville-NashP. COX-1,COX-2,and C0X-3 and the future treatment of chronic inflammatory disease[J].Lancet,2000,(9204):646-646.doi:10.1016/S0140-6736(99)12031-2.
  • 9Qin N,Zhang SP,Reitz TL. Cloning,Expression,and Functional Characterization of Human Cyclooxygenase-1 Splicing Variants:Evidence for Intron 1 Retention[J].Journal of Pharmacology and Experimental Therapeutics,2005,(3):1298-1130.doi:10.1124/jpet.105.090944.
  • 10Niknami M,Vignarajan S,Yao M. Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action:A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells[J].Biochimica Et Biophysica Acta,2010,(07):731-737.doi:10.1016/j.bbalip.2010.03.003.

同被引文献59

  • 1王顺文.COX-2与NF-κB在食管癌组织中的表达及关系[J].胃肠病学和肝病学杂志,2004,13(6):595-597. 被引量：9
  • 2李志刚,郎景和,冷金花,刘东远,刘珠凤,孙大为,朱兰.NS-398与前列腺素E_2对子宫内膜异位症子宫内膜细胞环氧合酶-2mRNA表达与凋亡的影响[J].现代妇产科进展,2005,14(1):30-33. 被引量：5
  • 3Dewitt D L,Swith W L.Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence[J].Proc Natl Acad Sci USA,1988,85(5):1412-1416.
  • 4Botting R.Paracetamol-inhibitable COX-2[J].J Physiol Pharmacol,2000,51(4 Pt 1):609-618.
  • 5Chandrasekharan N,Dai H,Roos K,et al.COX-3,a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs:cloning,structure,and expression[J].Proc Natl Acad Sci USA,2002,99(21):13926-13931.
  • 6Davies NM,Good RL,Roupe KA,et al.Cyclooxygenase-3:axiom,dogma,anomaly,enigma or splice error-Not as easy as 1,2,3[J].J Pharm Pharm Sci,2004,7(2):217-226.
  • 7Schwab J M,Schluesener H J,Meyermann R,et al.COX-3 the enzyme and the concept:Steps towards highly specialized pathways and precision the rapeutics[J].Prostaglandins Leukot Essent Fatty Acids,2003,69(5):339-343.
  • 8Pontiki E,Hadjipavlou-Litina D,Litinas K,et al.Design,synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities[J].Eur J Med Chem,2011,46(1):191-200.
  • 9Hayashi S,Ueno N,Murase A,et al.Novel acid-type cyclooxygenase-2 inhibitors:Design,synthesis,and structure activity relationship for anti-inflammatory drug[J].Eur J Med Chem,2012,50:179-195.
  • 10Steinmeyer J.Pharmacological basis for the therapy of pain and inflammation with non-steroidal anti-inflammator drugs[J].Arthritis Res,2000,2(5):379-385.

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求医问药（下半月刊）
2012年 第2期

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