血管内皮生长因子及其受体与IgA肾病

Relationship between VEGF/VEGFRs and IgA Nephropathy

IgA肾病血管内皮生长因子及其受体(VEGF/VEGFR)在肾脏组织局部、血浆及尿液中的含量发生变化。VEGF/VEGFR通过改变内皮细胞的结构和功能、增加肾小球毛细血管通透性、诱导细胞外基质合成、血管生成障碍等机理参与IgA肾病的发生与进展。

The vascular endothelial growth factor and vascular endothelial growth factor receptors （VEGF/VEGFRs） are important cytokines which control microvascular endothelial cell growth. In IgA nephropathy （IgAN） patients, the concentrations of VEGF and VEGFRs in kidney tissues, plasma and urine are different, compared with healthy people. VEGF/VEGFRs promote the occurrence and progression of IgAN via changing the structure and function of endothelial cells, increasing the permeability of glomerular capillary, inducting extracellular matrix synthesis and angiogenesis obstacles.