心脉隆注射液对动脉粥样硬化大鼠血管内皮细胞的保护作用

Protective Effect of Xinmailong Injecta on Vascular Endothelial Cells of Atherosclerosis Rats

目的探讨心脉隆注射液对动脉粥样硬化(AS)大鼠血管内皮细胞的保护作用.方法采用高脂饲料加维生素D3喂养8周的方法建立动脉粥样硬化大鼠的模型.将大鼠随机分为正常组、模型组、辛伐他汀组、心脉隆治疗组四组,高脂饲料喂养8周后取血测一氧化氮(NO)、内皮素(ET)、前列环素(PGI2)和血栓素(TXA2)的含量.结果心脉隆注射液给药8周后能明显的升高AS大鼠血清NO和血浆PGI2水平(P<0.05),显著降低血浆ET的含量(P<0.05).结论心脉隆注射液能保护AS大鼠血管内皮细胞,减轻动脉粥样硬化的进程,对动脉粥样硬化有治疗作用.

Objective To study the protective effect of Xinmailong（XML） injecta on vascular endothelial cells of the atherosclerosis Rats.Methods AS model of rat was made by feeding high grease food and Vitamin D3,and randomly divided into 4 groups including normal group,model group,simvastatin group and XML injecta group.The contents of NO,ET,PGI2,TXA2 were tested after the rat model of Atherosclerosis was established by feeding high lipid diet for 8 weeks.Results Compared with that of normal group the levels of NO,PGI2 in the XML injecta group increased significantly and the levels of ET decreased notably（P〈0.05）.Conclusion XML injecta had the effects of protecting vascular endothelial cells of the atherosclerosis rats and could inhibit the formation and development of atherosclerosis.