骨细胞分泌sclerostin抑制骨形成

Bone Formation Inhibition Role of Sclerostin Secreted by Osteocyte

骨细胞可以感受理化刺激然后分泌多种信号分子调节骨重建.Sclerostin是成熟性骨细胞分泌的一种抑制骨形成的糖蛋白.对sclerostin的发现、分泌细胞类型、分子特点和作用受体进行了简单回顾,并介绍sclerostin抑制成骨作用的信号通路,重点介绍sclerostin通过Wnt信号抑制成骨作用的分子机制.随后对基于sclerostin的作用机制设计药物用于治疗骨丢失的前景进行了展望.

Under physico-chemical stimulations,osteocytes secret multiple signal molecules to regulate bone remodeling.Sclerostin is a kind of glycoside protein secreted by mature osteocytes and inhibits bone formation.In this paper,we review the discovery,category of secretory cell,molecular features and action receptor of sclerostin and give an introduction to the signal pathway of sclerostin in inhibiting bone remodeling.We mainly address the molecular mechanism of sclerostin in inhibiting bone formation through Wnt signal.Based on the functional mechanism of sclerostin,we predict the possible treatment of bone loss.