抑郁症动物模型及行为学评价

Animal Models of Neuropsychiatric Disorders and Behavioral Tests

抑郁症的发病率高达20%,而针对抑郁症可用的药物及治疗方法相对匮乏.由于抑郁的许多症状具有主观性,其没有明显生物标志和客观的诊断试验,同时对抑郁症的发病机理缺乏基本的了解,因此用动物模拟人类的抑郁症是具有挑战性的.然而不断改善的动物模型将会对探索人类精神障碍疾病病理生理机制和治疗提供帮助.综述了在探索抑郁症发病机制及治疗方法方面用到的动物模型及动物行为学测试等研究方法.

The incidence of depression is as high as 20%.The drugs availablefor the treatment is relatively scarce.Since many symptoms of depression are of subjective nature,with no obvious biomarkers and objective diagnostic tests,and with a lack of basic understanding of its pathogenesis,it is extremely challenging to use animals for modeling human depression.Neverthe-less,improved animal models would be beneficial to a better understanding of the pathophysiology and treatment of human mental disturbance disease.This paper gives an overview of the animal models and animal behavioral tests applied in exploring the pathogenesis and treatment of depression.