改良悬雍垂腭咽成形术对中重度OSAHS患者血流介导的血管扩张功能的影响

Effect of H-uvulopalatopharyngoplasty on endothelium dependent flow-mediated dilation in patients with moderate to severe obstructive sleep apnea syndrome

目的:评价中、重度OSAHS患者血流介导的血管扩张功能(FMD)的改变及改良悬雍垂腭咽成形术(H-UPPP)对其FMD的影响。方法:选取49例经PSG确诊且未经治疗并排除其他疾病的中、重度OSAHS患者为实验组,45例PSG检查正常的健康人为对照组,应用彩色多普勒超声显像仪测定2组患者的FMD水平,实验组患者接受H-UPPP后6个月复查PSG、FMD。结果:实验组H-UPPP术后6个月、对照组与实验组H-UPPP术前比较,AHI、LSaO2、平均SaO2及FMD水平均差异有统计学意义(均P<0.01)。实验组H-UPPP术后6个月FMD[(9.7±2.7)%]较术前[(6.5±2.1)%]明显改善(P<0.01)。结论:中、重度OSAHS患者FMD减弱,H-UPPP可改善其FMD。

Objective：This study evaluates the effects of H-uvulopalatopharyngoplasty（H-UPPP） on endothelial function by endothelium dependent flow-mediated dilation（FMD） in patients with moderate to severe obstructive sleep apnea syndrome（OSAHS）.Method：Forty-five healthy subjects and 49 patients with moderately to severe OSAHS who desired H-UPPP were prospectively enrolled.FMD was measured by high-resolution B-mode ultrasonography.All subjects participated in sleep studies.These studies were repeated 6 months after H-UPPP in patients with moderately to severe OSAHS.Result：There was significant difference in FMD between patients with moderately to severe OSAHS and healthy subjects at baseline（6.5±2.1）% vs（11.2±3.1）%（P 0.01）.FMD increased from（6.5±2.1）% to（9.7±2.7）% 6 months after H-UPPP in patients with moderately to severe OSAHS（P0.01）.Conclusion：FMD is decreased in patients with moderately to severe OSAHS,H-UPPP treatment of these patients leads to improvement of FMD.