黄连软膏处方优化与流变学考察

Formulation Optimization and Rheology Determination of Huanglian Ointment

目的:优选黄连软膏的基质处方并测定其流变学参数。方法:以外观、稳定常数、冷热破坏等因素的综合评分为考察指标,采用均匀设计法优化黄连软膏处方,并测定流变学参数。结果:优化处方为十八醇12.060 g,单硬脂酸甘油酯10.018 g,聚山梨醇酯-80 7.831 g,山梨醇酐单油酸酯-60 3.173 g,黄连软膏流变学参数(黏度、屈服值、触变性、蠕变等)优良。结论:优选基质处方稳定可行,外观良好,黏度、延展性符合生产与临床应用需要。

Objective： To optimize matrix prescription and determine rheological parameters of Huanglian ointment.Method： With appearance,stability constant,hot and cold damage and other factors as indexes,prescription of Huanglian ointment was optimized by uniform design method,and determined rheological parameters.Result： Optimized prescription was octadecanol 12.060 g,monostearate 10.018 g,tween-80 7.831 g,span-60 3.173 g,rheological parameters（viscosity,yield value,thixotropy,creep etc.） of Huanglian ointment were fine.Conclusion： Optimized matrix prescription was stable and feasible,it had good appearance,viscosity and ductility which were suitable for needs of production and clinical applications.