正交设计法优选解毒通络颗粒提取工艺

Optimization of Extraction Process of Jiedu Tongluo Granule by Orthogonal Design

目的:正交试验法优选解毒通络颗粒处方药材的提取工艺。方法:以出膏率、丹酚酸B及天麻素为考核指标,采用L9(34)正交试验考察解毒通络颗粒处方药材提取工艺条件。结果:解毒通络颗粒处方药材的最佳提取工艺为10倍量70%乙醇提取3次,每次提取1.5 h。结论:该提取工艺稳定可行,省时、省工、节能,适合于工业化大生产,为解毒通络颗粒的制剂研究奠定基础。

Objective：To optimize extraction process of prescription drugs from Jiedu Tongluo granule by orthogonal test.Method：With extract rate,salvianolic acid B and gastrodin as indexes,extraction technology conditions of Jiedu Tongluo granule was investigated by L9（34） orthogonal test method.Result： Optimum extraction technology was：extracted 3 times with 1.5 h each time by 10 times the amount of 70% ethanol.Conclusion： This optimized extraction technology was stable,feasible.Meanwhile,it could save time,labor and energy and be suitable for industrial mass production,it could settle foundation for preparation of Jiedu Tongluo granule.