织纹螺体内的河豚毒素及其衍生物(英文)

Tetrodotoxin and Its Derivatives in Gastropods (Nassarius)

对2002年福建省引起食物中毒的织纹螺毒素进行研究。高效液相色谱-质谱联用(liquid chromatography/mass,LC/MS)的分析结果显示,织纹螺毒素的主要成分是河豚毒素类毒素(tetrodotoxin,TTX),另外还含有4-epiTTX、anhydroTTX、deoxyTTX等成分。生物法对织纹螺毒素的毒力测定结果表明:所收集的26个织纹螺样品中15个检测出毒性,毒素的毒力在5.7～47.3MU·g-1之间。毒力最高的织纹螺样品2003年5月1日来自福安,主要由半褶织纹螺和另一未定种组成。

Toxins in Nassarius gastropods during food intoxication event in Fujian Province in 2002 were studied.The toxin extracted from the gastropods was analyzed by high-performance liquid chromatography/mass spectrometry,and the result indicated that the toxin consisted of tetrodotoxin （TTX） and its derivatives,i.e.,4-epi TTX,deoxyTTX,as well as anhydroTTX.The toxic equivalent of the toxins was also detected by the bioassay approach,and the results indicated that 15 gastropods were confirmed to be positive among 26 samples,the toxicity in samples ranged from 5.7 to 47.3 mouse units per gram （MU·g-1）.The gastropods with highest toxicity was collected from Fu＇an on May 1,2003,which were consisted of two species,i.e.,Nassarius semiplicatus and a species not yet documented.