慢性重型乙型肝炎患者血清IL-23水平检测及其意义

Determination of serum IL-23 and its significance in patients with severe chronic hepatitis B

目的检测慢性重型乙型肝炎患者血清中IL-23表达，探讨IL-23水平与丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBil）及HBVDNA载量的相关性。方法用酶联免疫吸附法（ELISA）检测50例慢性重型乙型肝炎患者（重肝组）及18名健康人（对照组）血清中IL-23表达，并与患者ALT、AST、TBil、HBVDNA载量进行相关性分析。结果重肝组患者血清中IL-23表达高于对照组，两组之间的差异有统计学意义（P〈0．05）；IL-23水平与ALT、AST呈正相关（P〈0．05），与TBil、HBVDNA载量无相关性（P〉0．05）。结论慢性重型乙型肝炎患者血清中IL-23表达增高，与炎症程度相关，可能参与慢性重型乙型肝炎的发病。

Objective To investigate the level of the serum IL-23 and its correlation with serum biochemical indices of liver function tests and HBV DNA load in patients with chronic severe hepatitis B. Methods Fifty patients with chronic severe hepatitis B （severe hepatitis group） and 18 healthy controls （control group） were enrolled in the study. The serum IL-23 expression level was detected by ELISA method. The correlation between IL-23 and ALT, AST, TBil, HBV DNA load was analyzed using Pearson＇s correlation analysis, respectively. Results Serum IL-23 expression level in severe hepatitis group was significantly higher than that of control group （P 〈 O. 05）. Serum IL-23 level was positively correlated with serum ALT, AST, respectively （P 〈 O. 05 ） , but was not correlated with TBil and HBV DNA load, respectively （P 〉 0. 05）. Conclusion Serum IL-23 expression level was increased in patients with chronic severe hepatitis B and was associated with the severe of inflammation. We, therefore, believe that IL-23 might be involved in the pathogenesis of chronic severe hepatitis B.