复方苦瓜胶囊降血糖活性的初步观察

Observation on Function of Compound Momordica Charantia L. Capsule for Reducing Blood Glucose

目的观察复方苦瓜胶囊的降血糖作用。方法给小鼠注射四氧嘧啶建立高血糖动物模型，然后随机分成3个实验组（225mg／kg、450mg／kg、900mg／kg）和1个模型对照组，连续灌胃受试物30d后比较实验组和对照组的空腹血糖、血糖下降百分率及糖耐量值，同时用正常小鼠进行降低空腹血糖实验。结果高血糖模型小鼠的复方苦瓜胶囊900mg／kg和450mg／kg剂量组的空腹血糖明显低于模型对照组（p〈0.01），血糖下降百分率明显大于模型对照组（P〈0．01），高血糖模型小鼠的糖耐量值和正常小鼠的空腹血糖未见受到明显影响。结论复方苦瓜胶囊具有降低小鼠空腹血糖的作用，而对糖耐量和正常小鼠的空腹血糖无明显影响。

Objective To investigate the function of Compound Momordica Charantia L. capsule for reducing blood glucose. Methods Mice were injected with alloxan to build hyperglycemia animal model and then randomly divided into three test groups （225,450, 900mg/kg） and model control group. The mice were administered with the compound for 30 days, then the fasting blood-glucose and sugar tolerance between test groups and control group were compared. Normal mice were chosen to carry out the test of reducing fasting blood - glucose at the same time. Results The fasting blood - glucose was obvious lower than that of model control group （P〈0.01）, and the blood-glucose decline rate was greater than that of control group （P〈0.01） in the hyperglycemia model mice of 900 and 450 mg/kg group. There were not significant difference between the sugar tolerance of test groups and model control group in hyperglycemia model mice and between the fasting blood - glucose of test group and model control group in normal mice. Conclusion Compound momordica charantia L. capsule had the function for reducing blood-glucose.