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Ezrin和c-Met在胃癌组织中的表达及意义 被引量：6

Expression and significance of Ezrin and c-Met in gastric carcinoma
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摘要 目的研究Ezrin和c-Met在胃癌组织中的表达及其临床意义。方法应用免疫组织化学法检测45例胃癌、25例胃腺瘤、20例正常胃黏膜组织中Ezrin和c-Met的表达水平,分析Ezrin和c-Met的表达与各临床病理因素的关系。结果胃癌组织中Ezrin和c-Met的表达水平明显高于胃腺瘤组织及正常胃黏膜组织(P<0.05)。Ezrin和c-Met的表达水平与肿瘤的浸润深度、分化程度及有无淋巴结转移/远处转移有关(P<0.05),与性别、年龄及肿瘤大小无关(P>0.05),两者在胃癌组织中的表达呈正相关关系(r=0.603,P<0.001)。结论 Ezrin和c-Met与胃癌的发生、侵袭、转移密切相关,二者在胃癌发生、发展过程中可能具有协同作用,联合检测Ezrin和c-Met的表达水平可能为胃癌预后判断提供依据。 Objective To investigate the expression of Ezrin and c-Met in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was applied to detect the expression of Ezrin and c-Met in 45 cases of gastric carcinoma,25 cases of gastric adenoma and 20 cases of normal gastric mucosa.The relationships between their expression and the clinicopathological parameters were analyzed. Results The expression of Ezrin and c-Met in gastric carcinoma was significantly higher than those in gastric adenoma and normal gastric mucosa（P0.05）.The expression of Ezrin and c-Met was related to the invasion depth,the degree of differentiation and lymph node metastasis or distant metastasis（P0.05）,but not to gender,age and tumor diameter（P0.05）.A positive correlation was found between Ezrin and c-Met expression in gastric carcinoma tissues（r=0.603,P0.001）. Conclusion Ezrin and c-Met are closely related to the development,invasion and metastasis of gastric carcinoma.Ezrin and c-Met are synergic in the occurrence and development of gastric carcinoma.Combined detection of Ezrin and c-Met is helpful for clinical doctors to predict the prognosis in patients with gastric carcinoma.
作者 张庆飞 杨兵
机构地区 广东医学院附属医院消化内科 广东省深圳市龙岗中心医院消化内科
出处 《山西医科大学学报》 CAS 2012年第4期257-259,318,共4页 Journal of Shanxi Medical University
关键词 胃癌 EZRIN C-MET 免疫组织化学 gastric carcinoma Ezrin c-Met immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
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参考文献8

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二级参考文献8

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共引文献11

同被引文献84

  • 1许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量：1363
  • 2张岩,胡美玉,陈碧华,王志军,查锡良,刘康达.体外RNA干扰下调ezrin表达对肝癌细胞生长和运动能力的影响[J].中华医学杂志,2006,86(8):530-535. 被引量：13
  • 3熊正文,曲延静,黄勇,李宏伟,胡海霞.光波-微波组合技术在肠道标本石蜡切片与免疫组化染色中的应用[J].华北国防医药,2006,18(5):312-314. 被引量：7
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  • 5王风婷.C-met和COX-2在非小细胞肺癌中的表达与临床意义[J].井冈山大学学报,2013,34(1):95-100.
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引证文献6

二级引证文献17

山西医科大学学报
2012年 第4期

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